How to microdose with 4-AcO-DMT
Usually sold in powder form, 4-AcO-DMT can be taken orally or intranasally, among other methods. But for microdosing, oral administration seems to be the most obvious choice—if only for ease and simplicity. Be warned, though: it tastes pretty foul.
When measuring out doses, keep in mind that just a few milligrams can lead to profoundly different effects. Going off of anecdotal reports, effective microdoses range between 0.5 mg and 5 mg, though 5 mg may be too much for most people—that much could produce a noticeable come-up, difficulty focusing, and scattered thoughts in general. 1 mg is a good place to start, knowing that it may be adjusted up or down as required on subsequent occasions. But since most affordable scales (such as the Gemini-20) are incapable of accurately weighing such tiny amounts, volumetric microdosing is probably your best bet.
It’s also worth noting that the precise concentration of your 4-AcO-DMT powder will depend on whether it’s in the form of a fumarate or hydrochloride (HCl) salt. Every 1.24 mg fumarate, for example, is expected to contain 1 mg 4-AcO-DMT, while the equivalent amount in HCl would be 1.15 mg for 1 mg 4-AcO-DMT.
Microdosing 4-AcO-DMT Volumetrically
A good way to keep your microdoses consistent is to dissolve a known amount of 4-AcO-DMT in a liquid solution and take proportionate amounts of that. If you dissolve 50 mg 4-AcO-DMT in 50 ml alcohol, for instance, then 1 ml of the solution will contain a reliable 1 mg of the substance—and this dose can be adjusted up or down in accordance with concentration, as well as squirted into the mouth, with a blunt 1-2 ml syringe.
To prepare a 4-AcO-DMT solution for microdosing:
- Weigh out 50 mg 4-AcO-DMT on an accurate milligram scale
- Add to a sterile amber glass (or opaque, e.g. foil-wrapped) bottle of 50 ml ethanol/ethyl alcohol or vodka
- Seal and shake the bottle, then leave to stand overnight
- Store in the freezer. 4-AcO-DMT should last for up to two years if stored in ethanol at -20° C (-4°F)
It is possible to use distilled water as a solvent instead, but it will degrade the 4-AcO-DMT faster. This is especially true if you keep thawing and refreezing it between each dose, although a potential workaround could be to freeze individual microdoses separately in syringes.
Regardless of the choice of solvent, though, 4-AcO-DMT will generally last longer when it’s dry. For this reason, it’s best to prepare only small batches of the solution at once—perhaps no more than 10 mg at a time or enough to last a few weeks, depending on your microdose schedule.
A more novel, and much less talked about, method of microdosing is to rub 4-AcO-DMT directly into the skin. For this, you’ll need to dissolve it in food grade propylene glycol to ensure efficient delivery into the bloodstream. One user discovered this method accidentally while preparing a solution for vaping; they mixed 100 mg 4-AcO-DMT in 3 ml propylene glycol and rubbed two to three drops into their neck after showering.
Keep in mind, however, that allergic reactions to propylene glycol are not uncommon and symptoms include dryness, itchiness, swelling, rashes, and burning sensations.  To minimize the risk, sample a small amount first and wait two or three days for symptoms to appear, discontinuing use if they do. You can also try a vegetable glycerin instead.